Professor Emeritus
B.S. Chemistry, M.S. Biochemistry, Ph.D. Molecular Biology and Biotechnology, University of the Philippines, 1970, 1981, 1996
email:
Research interests:
Peptide and Protein Chemistry, Proteomics, Toxinology
Patents:
Walker CS, Shetty R, Jimenez EC, McIntosh JM, Olivera BM, Watkins M, Jones RM, Shen GS (2004) I-superfamily conotoxins. U. S. Patent 6,767,895.
Abogadie FC, Cruz LJ, Olivera BM, Walker C, Colledge C, Hillyard DR, Jimenez EC, Layer RT, Zhou L, Shen GS, McCabe RT, Rivier JE (2003) Conantokins. U. S. Patent 6,515,103.
Jimenez EC, Olivera BM, Gray WR, Cruz LJ (2002) Contryphan peptides. U. S. Patent 6,441,132.
Jacobsen R, Jimenez EC, Cruz LJ, Olivera BM, Gray WR, Grilley M, Watkins M, Hillyard DR (2000) Contryphan peptides. U. S. Patent 6,153,738.
Jacobsen R, Jimenez EC, Cruz LJ, Olivera BM, Gray WR, Grilley M, Watkins M, Hillyard DR (2000) Contryphan peptides. U. S. Patent 6,077,934.
Cruz LJ, Olivera BM, McIntosh JM, Jimenez EC, Craig AG, Rivier JA, Julius D, England L (1999) Bromotryptophan conopeptides. U. S. Patent 5,889,147.
Articles published in Web of Science-indexed and/or Scopus-indexed journals:
Subong BJS, Subong BJJ, Benico GA, Sulit AKL, Mendoza CO, Cruz LJ, Azanza RV, Jimenez EC. (2017) Toxicity and protein expression of Alexandrium species collected in the Philippine waters. Phil J Sci 146:425-436.
Jimenez EC (2017) D-amino acid-containing peptides in Conus venoms. Phil Sci Lett 10:72-80.
Mendoza CO, Rabanes AC, Jimenez EC, Azanza RV, Cortez-Akhunzadah J, Cruz LJ (2013) Detection of ciguatera fish poisoning in the Philippines. J Envi Sci Management. Special Issue 1:50-55.
Jimenez EC (2013) Diversity of Conus peptides that target the nicotinic acetylcholine receptors. Phil Sci Lett 6:8-15.
Jimenez EC, Olivera BM (2010) Divergent M- and O-superfamily peptides from venom of fish-hunting Conus parius. Peptides 31:1678-1683.
Jimenez EC (2009) Conantokins: from “sleeper” activity to drug development. Phil Sci Lett 2:60-66.
Jimenez EC, Sasakawa N, Kumakura K (2008) Effects of sodium channel-targeted conotoxins on catecholamine release in adrenal chromaffin cells. Phil J Sci 137:127-132.
Buczek O, Jimenez EC, Yoshikami D, Imperial JS, Watkins M, Morrison A, Olivera BM (2008) I1-superfamily conotoxins and prediction of single D-amino acid occurrence. Toxicon 51:218-229.
Teichert RW, Jimenez EC, Twede V, Watkins M, Hollmann M, Bulaj G, Olivera BM (2007) Novel conantokins from Conus parius venom are specific antagonists of NMDA receptors. J Biol Chem 282: 36905-36913.
Jimenez EC, Olivera BM, Teichert RW (2007) AlphaC-Conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry 46:8717-8724.
Jimenez EC (2007) Contryphans revisited. Current Topics Peptide Protein Res 8:11-17.
Buczek O, Yoshikami D, Watkins M, Bulaj G, Jimenez EC, Olivera BM (2005) Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily. FEBS J 272:4178-4188.
Corpuz GP, Jacobsen RB, Jimenez EC, Watkins M, Walker C, Colledge C, Garrett JE, McDougal O, Li W, Gray WR, Hillyard DR, Rivier J, McIntosh JM, Cruz LJ, Olivera BM (2005) Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. Biochemistry 44:8176-8186.
Teichert RW, Jimenez EC, Olivera BM (2005) AlphaS-conotoxin RVIIIA: A structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors. Biochemistry 44:7897-7902.
Buczek O, Yoshikami D, Bulaj G, Jimenez EC, Olivera BM (2005) Posttranslational amino acid isomerization:A functionally important D-amino acid in an excitatory peptide. J Biol Chem 280:4247-4253.
Jimenez EC, Watkins M, Olivera BM (2004) Multiple 6-bromotryptophan residues in a sleep-inducing peptide. Biochemistry 43, 12343-12348.
Bulaj G, Buczek O, Goodsell I, Jimenez EC, Kranski J, Nielsen JS, Garrett GE, Olivera BM (2003) Efficient oxidative folding of conotoxins and the radiation of venomous cone snails. Proc Natl Acad Sci U.S.A. 100 Suppl. 2:14562-14568.
Jimenez EC, Shetty RS, Lirazan M, Rivier J, Walker C, Abogadie FC, Yoshikami D, Cruz LJ, Olivera BM (2003) Novel excitatory Conus peptides define a new conotoxin superfamily. J Neurochem 85:610-621.
Jimenez EC, Donevan S, Walker C, Zhou L, Nielsen J, Cruz LJ, Armstrong H, White HS, Olivera BM (2002) Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency. Epilepsy Res 51:73-78.
Lirazan MB, Jimenez EC, Craig AG, Olivera BM, Cruz LJ (2002) Conophysin-R, a Conus radiatus venom belonging to the neurophysin family. Toxicon 40:901-908.
Jimenez EC, Watkins M, Juszsak L, Cruz LJ, Olivera BM (2001) Contryphans from Conus textile venom ducts. Toxicon 39:803-809.
Pallaghy PB, He W, Jimenez EC, Olivera BM, Norton RS (2000) Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis-trans isomerism. Biochemistry 39:12845-12851.
Pallaghy PB, Melnikova AP, Jimenez EC, Olivera BM, Norton RS (1999) Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing D-tryptophan: comparison with protein loops. Biochemistry 38:11553-11558.
Jacobsen R, Jimenez EC, De la Cruz R, Gray WR, Cruz LJ, Olivera BM (1999) A novel D-leucine-containing Conus peptide: diverse conformational dynamics in the contryphan family. J Peptide Res 54:93-98.
Jacobsen R, Jimenez EC, Grilley M, Watkins M, Hillyard D, Cruz LJ, Olivera BM (1998) The contryphans, a D-tryptophan-containing family of Conus peptides. J Peptide Res 51:173-177.
Mccabe T, Olivera BM, Jimenez E, Cruz LJ, Zhou LM, White HS (1997) Anticonvulsant profile of conantokin-R: A novel and selective antagonist at the NMDAR1-1b/NR2b subunit. Epilepsia 38:220.
Craig AG, Jimenez EC, Dykert J, Nielsen DB, Gulyas J, Abogadie FC, Porter J, Rivier J, Cruz LJ, OliveraBM, McIntosh JM (1997) A novel post-translational modification involving bromination of tryptophan: identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venom. J Biol Chem 272:4689-4698.
Jimenez EC, Craig AG, Watkins M, Hillyard DR, Gray WR, Gulyas J, Rivier JE, Cruz LJ, Olivera BM (1997) Bromocontryphan: post-translational bromination of tryptophan. Biochemistry 36:989-994.
Jimenez EC, Olivera BM, Gray WR, Cruz LJ (1996) Contryphan is a D-tryptophan containing Conus peptide. J Biol Chem 271:28002-28005.
Jimenez EC, Pocsidio GN (1994) Blood glucose levels of Oreochromis niloticus exposed to chloropyriphos. Phil J Sci 123:171-175.
Shimizu A, Jimenez EC, Takagi J, Inada Y, Saito Y (1987) Venom from southern copperhead snake (Agkistrodon contortrix contortrix). I. Characterization of a protease that preferentially releases fibrinopeptide B. Toxicon 25:751-757.
Jimenez EC, Olivera BM, Cruz LJ (1983) Localization of enzymes and possible toxin precursors in granules from Conus striatus venom. Toxicon Suppl. 3:199-202.
Chapters in books:
Jimenez EC, Cruz LJ (2016) Conotoxins as tools in research on nicotinic receptors. In: Toxins and Drug Discovery. Gopalakrishnakone P et al. (eds) Springer: The Netherlands, Chapter 17, pp. 1-17.
Teichert RW, Jimenez EC, Olivera BM (2009) Biology and pharmacology of conotoxins. In: Botulinum Toxin: Therapeutic Clinical Practice and Science. Jankovic J, Albanese A, Atassi MZ, Dolly JO, Hallett M, Mayer N (eds) Philadelphia: Elsevier, pp. 446-464.
Cruz LJ, Jimenez EC (2004) Conus venom neuropeptides. In: Encyclopedia of Neuroscience, 3rd ed, CD-ROM version. Adelman G, Smith BH (eds) Amsterdam and New York: Elsevier.
Essays in books:
Jimenez EC (2017) Cellular respiration and dieting. In: Science Philippines, Essays on Science by Filipinos, vol. IV, Concepcion GP (ed) Quezon City: UP Press, pp. 146-149.
Jimenez EC (2017) Fats in us. In: Science Philippines, Essays on Science by Filipinos, vol. IV, Concepcion GP (ed) Quezon City: UP Press, pp. 150-154.
Jimenez EC (2017) My notes on collagen. In: Science Philippines, Essays on Science by Filipinos, vol. IV, Concepcion GP (ed) Quezon City: UP Press, pp. 157-159.
Jimenez EC (2017) A trendy substance called glutathione. In: Science Philippines, Essays on Science by Filipinos, vol. IV, Concepcion GP (ed) Quezon City: UP Press, pp. 160-162.
Jimenez EC (2017) Botulinum toxin: from poison to cosmetics and medication. In: Science Philippines, Essays on Science by Filipinos, vol. IV, Concepcion GP (ed) Quezon City: UP Press, pp. 163-165.
Jimenez EC (2017) Protein, first…and when it goes awry. In: Science Philippines, Essays on Science by Filipinos, vol. III, Concepcion GP (ed) Quezon City: UP Press, pp. 113-117.
Jimenez EC (2017) The tale of insulin and the episodes of hyperglycemia and hypoglycemia. In: Science Philippines, Essays on Science by Filipinos, vol. III, Concepcion GP (ed) Quezon City: UP Press, pp.127-129.
Jimenez EC (2017) On love darts and poison darts. In: Science Philippines, Essays on Science by Filipinos, vol. III, Concepcion GP (ed) Quezon City: UP Press, pp. 154-156.
Jimenez EC (2016) The scientific method: when science is done well. In: Towards Excellence in Science Research: A UP Research Guidebook, version 1. Almoro PF, Dimalanta CB, Morta AT (eds) Quezon City: UP Office of the Vice President for Academic Affairs, pp. 31-37.
Jimenez EC (2013) Beyond aspirin and morphine, snail toxins for pain. In: Science Philippines, Essays on Science by Filipinos, vol. II. Concepcion GP (ed) Quezon City: UP Press, pp. 158-160.
Jimenez EC, Patacsil MC (2012) To D or not to D: an amino acid mystery unveiled. In: Science Philippines, Essays on Science by Filipinos, vol. I. Concepcion GP (ed) Quezon City: UP Press, pp. 123-125.
Jimenez EC (2008) Protein modification: To D or not to D. In: Selected Essays on Science and Technology for Securing a Better Philippines. Concepcion GP, Padlan EA, Saloma C (eds) Quezon City: UP Press, pp. 266-268.
